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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 3
1947 9
1948 5
1949 3
1950 14
1951 11
1952 22
1953 41
1954 24
1955 36
1956 46
1957 38
1958 29
1959 37
1960 38
1961 60
1962 63
1963 214
1964 410
1965 149
1966 2
1967 6
1968 4
1969 6
1970 13
1971 7
1972 3
1973 45
1974 51
1975 110
1976 137
1977 133
1978 187
1979 198
1980 231
1981 225
1982 250
1983 345
1984 386
1985 366
1986 414
1987 433
1988 535
1989 697
1990 712
1991 764
1992 862
1993 913
1994 1223
1995 1235
1996 1230
1997 1378
1998 1482
1999 1702
2000 1807
2001 2068
2002 2553
2003 3030
2004 3711
2005 4095
2006 4435
2007 5135
2008 5820
2009 6113
2010 6036
2011 6784
2012 7129
2013 7947
2014 8652
2015 9218
2016 8392
2017 7941
2018 9296
2019 9971
2020 10861
2021 11776
2022 11758
2023 10640
2024 3772

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166,458 results

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Page 1
Refinement of experimental design and conduct in laboratory animal research.
Bailoo JD, Reichlin TS, Würbel H. Bailoo JD, et al. ILAR J. 2014;55(3):383-91. doi: 10.1093/ilar/ilu037. ILAR J. 2014. PMID: 25541540 Review.
The scientific literature of laboratory animal research is replete with papers reporting poor reproducibility of results as well as failure to translate results to clinical trials in humans. This may stem in part from poor experimental design and conduct of a …
The scientific literature of laboratory animal research is replete with papers reporting poor reproducibility of results as well as f …
The Positivism Paradigm of Research.
Park YS, Konge L, Artino AR Jr. Park YS, et al. Acad Med. 2020 May;95(5):690-694. doi: 10.1097/ACM.0000000000003093. Acad Med. 2020. PMID: 31789841
Research paradigms guide scientific discoveries through their assumptions and principles. ...An example from health professions education is provided to guide positivist thinking in study design and implementation....
Research paradigms guide scientific discoveries through their assumptions and principles. ...An example from health professions educa …
Animal experimental research design in critical care.
Merkow JS, Hoerauf JM, Moss AF, Brainard J, Mayes LM, Fernandez-Bustamante A, Mikulich-Gilbertson SK, Bartels K. Merkow JS, et al. BMC Med Res Methodol. 2018 Jul 5;18(1):71. doi: 10.1186/s12874-018-0526-6. BMC Med Res Methodol. 2018. PMID: 29976162 Free PMC article.
BACKGROUND: Limited translational success in critical care medicine is thought to be in part due to inadequate methodology, study design, and reporting in preclinical studies. The purpose of this study was to compare reporting of core features of experimental rigor: …
BACKGROUND: Limited translational success in critical care medicine is thought to be in part due to inadequate methodology, study design …
Teaching experimental design.
Fry DJ. Fry DJ. ILAR J. 2014;55(3):457-71. doi: 10.1093/ilar/ilu031. ILAR J. 2014. PMID: 25541547 Review.
Awareness of poor design and published concerns over study quality stimulated the development of courses on experimental design intended to improve matters. ...A problem-solving approach can help develop the skills of deciding what are correct experimental …
Awareness of poor design and published concerns over study quality stimulated the development of courses on experimental de …
Quality of reporting of experimental research in implant dentistry. Critical aspects in design, outcome assessment and model validation.
Vignoletti F, Abrahamsson I. Vignoletti F, et al. J Clin Periodontol. 2012 Feb;39 Suppl 12:6-27. doi: 10.1111/j.1600-051X.2011.01830.x. J Clin Periodontol. 2012. PMID: 22533944 Review.
OBJECTIVE: The aim was to assess the quality of reporting of experimental research in implant dentistry by a critical evaluation of study design, outcome assessments and model validation. ...Studies on the pathogenesis and treatment of peri-implant diseases w …
OBJECTIVE: The aim was to assess the quality of reporting of experimental research in implant dentistry by a critical evaluati …
The place of experimental design and statistics in the 3Rs.
Parker RM, Browne WJ. Parker RM, et al. ILAR J. 2014;55(3):477-85. doi: 10.1093/ilar/ilu044. ILAR J. 2014. PMID: 25541549 Review.
Key to the success of this endeavor is an appreciation of the principles of good experimental design and analysis; these need to be considered in concert before any data is collected. Indeed, many of the principles central to helping achieve the objectives of the 3R …
Key to the success of this endeavor is an appreciation of the principles of good experimental design and analysis; these need …
Experimental toxicology: Issues of statistics, experimental design, and replication.
Briner W, Kirwan J. Briner W, et al. Neurotoxicology. 2017 Jan;58:137-142. doi: 10.1016/j.neuro.2016.11.002. Epub 2016 Dec 10. Neurotoxicology. 2017. PMID: 27965035 Review.
Issues with replication occur for a variety of reasons ranging from experimental design to laboratory errors to inappropriate statistical analysis. Here we review a variety of guidelines for statistical analysis, design, and execution of experiments in toxico …
Issues with replication occur for a variety of reasons ranging from experimental design to laboratory errors to inappropriate …
Animal husbandry and experimental design.
Nevalainen T. Nevalainen T. ILAR J. 2014;55(3):392-8. doi: 10.1093/ilar/ilu035. ILAR J. 2014. PMID: 25541541 Review.
Controlling all major variables as far as possible is the key issue when establishing an experimental design. The other common mechanism affecting study results is a change in the variation. ...Laboratory animal husbandry issues are an integral but underappreciated …
Controlling all major variables as far as possible is the key issue when establishing an experimental design. The other common …
Quality of design and reporting of animal research in peritoneal dialysis: A scoping review.
Witowski J, Sikorska D, Rudolf A, Miechowicz I, Kamhieh-Milz J, Jörres A, Bręborowicz A. Witowski J, et al. Perit Dial Int. 2020 Jul;40(4):394-404. doi: 10.1177/0896860819896148. Epub 2020 Jan 17. Perit Dial Int. 2020. PMID: 32063215 Review.
The concerns about reproducibility and validity of animal studies are partly related to poor experimental design and reporting. Here, we undertook a scoping review of the literature to determine the extent and quality of reporting of animal studies on peritoneal dia …
The concerns about reproducibility and validity of animal studies are partly related to poor experimental design and reporting …
Between two stools: preclinical research, reproducibility, and statistical design of experiments.
Reynolds PS. Reynolds PS. BMC Res Notes. 2022 Feb 21;15(1):73. doi: 10.1186/s13104-022-05965-w. BMC Res Notes. 2022. PMID: 35189946 Free PMC article.
Translation of animal-based preclinical research is hampered by poor validity and reproducibility issues. Unfortunately, preclinical research has 'fallen between the stools' of competing study design traditions. ...Problems are compounded by the lack of adequ …
Translation of animal-based preclinical research is hampered by poor validity and reproducibility issues. Unfortunately, preclinical …
166,458 results
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Searches related to "experimental research design"